Introduction

Severe and moderate Autistic Spectrum Disorder (ASD) patients exhibit an under-connectivity between sensory cortices and association cortices leading to a failure to assimilate sensory information into a working environmental context. Additionally, ASD patients have a lack of connectivity of associative cortices to the frontal cortex.  

 

 

Core CNS Symptoms in Moderate and Severe ASD Patients*

1. Impaired social communication and interaction.

 

2. Restricted, stereotyped and repetitive patterns of behaviour and interests.

3.    Other disorders of the CNS:

motor deficits                                 

speech disorders

sensory impairments                       

anxiety and phobias

epilepsy  

behavioural problems

sleep disorders

tics

delayed intellectual development

obsessive-compulsive disorder

 

*Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Rossignol, Frye  Mol Psychiatry. 2012 Mar;17(3):290-314. doi: 10.1038/mp.2010.136. Epub 2011 Jan 25.

 

These ASD CNS (central nervous system) symptoms are caused by:

1)      Impaired neurogenesis and apoptosis.

2)      Impaired synaptogenesis and synaptic pruning.

3)      Imbalanced excitatory-inhibition system.

Objective.

 

This site offers options on addressing the symptoms exhibited by ASD patients in order to improve the quality of life for moderate and severe ASD patients and their care givers.

 

This site describes an integrated approach to addressing ASD symptoms via supplementation with Speak (Omega 3 complex) in combination with both Hericor-MRL supplementation.

 

Speak

 

Speak is a proven supplement in a capsule form (1,5 ml) containing pharmaceutical grade Omega-3 with GLA and two specific types of Vitamins E and Vitamin K. Speak supplementation is gradually increased until a demonstrative change in behaviour or speech pattern is developed.

 

 

 

 

Hericor-MRL

 

Hericor-MRL supplementation addresses the gastrointestinal discomfort. In vitro studies demonstrate that constituents within Hericor-MRL have prebiotic activity and animal studies demonstrate the same constituents also increase Lipoxin A4 (leading to a reduction in neuroinflammation) in rats and increase neurogenic reserve in mice.

 

:

 

Day

0

7

14

21

28

35

42

49

56

63

70+

 

 

 

 

 

 

 

 

 

 

 

 

Speak

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hericor-MRL

 

 

 

 

 

 

 

 

 

 

 

 

 

 
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  

 

 

 

 

 

 

 

 

 

 

1 & 2

3 & 4

5 & 6

7 & 8

9 & 10

11 & 12

13 & 14

15 to 30

10 mg

20 mg

30 mgx

40 mgx

50 mgx

60 mgx

60 mgx

60 mgx

 

1

2

3

4

5

6

7

8

 

X

x

X

xx

xx

xx

xx

xx

 

 

x

X

x

xx

xx

xx

xx

 

 

 

X

x

x

xx

xx

xx

 

 

 

 

 

 

 

 

 

 

1

2

3

4

5

6

 

 

 

Hericor-MRL 

 

Simultaneously with CBD sublingual supplementation, administration of 4 g /day of Hericor-MRL (2 g/ with breakfast and 2g/ with lunch) should be followed for 60 days. The Hericor-MRL powder can be added to non-citric yoghurt or to the meal.  

 

Each 250 g tub of Hericor-MRL tub has a 2 g spoon. After the 60 day supplementation period the use of of Hericor-MRL should cease. Subsequent use should only be when gastrointestinal discomfort return.

Table II

Supplementation Plan

 

 

 

 

 

 

 

 

Gastrointestinal

 

 

 

 

 

 

 

 

Hericor -MRL 4 g per day

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Week

1

2

3

4

5

6

7

8 &9

Supplementation/day

4 g

4 g

4 g

4 g

4 g

4 g

4 g

4 g

Supplementatin * 2 g divided 

 

 

 

 

 

 

 

 

with breakfast

x

x

x

x

x

x

x

x

with lunch 

x

x

x

x

x

x

x

x

dinner

 

 

 

 

 

 

 

 

 

 

 

 

Speak

 

Speak is a Omega-3 complex with a variety of vitamins (see brochure) in a 1,5 ml soft gel twist off capsule. The supplementation should be 1 capsule (1,5 ml)  per day (with meals) for two weeks, then titrate up by an additional capsule for another two weeks and then continue until there is a change in behaviour (i.e. calm or verbal expression). If after a change in behaviour, there is not additional improvement at a higher supplementation level then return to the previous supplementation level.

Table III

 

 

 

 

 

 

 

 

Supplementation Plan

 

 

 

 

 

 

 

 

Speak Twist Off Capsules add to food

 

 

 

 

 

 

 

 

Omega 3 Complex

 

 

 

 

 

 

 

 

Titrate up 1 capsule every two weeks

 

 

 

 

 

 

 

 

Week

1

2

3

4

5 & 6

7 & 8

9 & 10

11 to 12

Capsule per day

1

1

2

2

3

4

5

6

 

 

 

 

 

 

 

 

 

with breakfast

X

x

x

x

x

xx

xx

xx

lunch 

 

 

x

x

x

x

xx

xx

dinner

 

 

 

 

x

x

x

xx

 

 

 

 

 

 

 

 

 

Tablets per Week

7

7

14

14

42

56

70

84

 

 

 

 

 

 

 

 

 

 

1.    Begin with 1 capsule of Speak (1,5 ml) daily with meals for two weeks and then increase gradually.

2.    Typical supplementation for small children (under 65 kilos) is 2 to 4 capsules per day (3 ,0 to 6,0ml per day).

3.    For older children (65 kilos+) 4 to 6 capsules per day (6,0 ml to 9,0 ml).

4.    It is recommended that Speak be taken for at least a minimum of 4 months.

When starting the protocol, there may be a change in bowel movements with loose stools and a  “runny tummy” . This condition should clear within five (5) to seven (7) days. If persists after five days discontinue use of product as this could cause dehydration.

 

Summary of Protocol:

 

In the first week, commence Hericor-MRL supplementation.  

 

After seven (7) days, commence Speak supplementation.

 

 

 

Discontinue Hericor-MRL supplementation after day 60.

 

Continue to use Speak supplementation to the supplementation level that provokes a beneficial change in behaviour.